计算分子生物学导论(英文版) pdf 下载 极速 mobi txt pdb lrf 网盘

Ever since the structure of DNA was unraveled in 1953, molecular biology has witnessed tremendous advances. With the increase in our ability to manipulate biomolecular sequences, a huge amount of data has been and is being generated. The need to process the information that is pouring from laboratories all over the world, so that it can be of use to further scientific advance, has created entirely new problems that are interdisciplinary in nature. Scientists from the biological sciences are the creators and ultimate users of this data. However, due to sheer size and complexity, between creation and use the help of many other diisciplines is required, in particular those from the mathematical and computing sciences. This need has created a new field, which goes by the general name of computational molecular biology.

Preface

Book Overview

Exercises

Errors

Acknowledgments

1 Basic Concepts of Molecular Biology

1.1 Life

1.2 Proteins

1.3 Nucleic Acids

1.3.1 DNA

1.3.2 RNA

1.4 The Mechanisms of Molecular Genetics

1.4.1 Genes and the Genetic Code

1.4.2 Transcription， Translation， and Protein Synthesis

1.4.3 Junk DNA and Reading Frames

1.4.4 Chromosomes

1.4.5 Is the Genome like a Computer Program?

1.5 How the Genome Is Studied

1.5.1 Maps and Sequences

1.5.2 Specific Techniques

1.6 The Human Genome Project

1.7 Sequence Databases

Exercises

Bibliographic Notes

2 Strings,Graphs,and Algorithms

2.1 Strings

2.2 Graphs

2.3 Algorithms

Exercises

Bibliographic Notes

Sequence Comparison and Database Search

3.1 Biological Background

3.2 Comparing Two Sequences

3.2.1 Global Comparison-The Basic Algorithm

3.2.2 Local Comparison

3.2.3 Semiglobal Comparison

3.3 Extensi*** to the Basic Algorithms

3.3.1 Saving Space

3.3.2 General Gap Penalty Functi***

3.3.3 Affine Gap Penalty Functi***

3.3.4 Comparing Similar Sequences

3.4 Comparing Multiple Sequences

3.4.1 The SP Measure

3.4.2 Star Alignments

3.4.3 Tree Alignments

3.5 Database Search

3.5.1 PAM Matrices

3.5.2 BLAST

3.5.3 FAST

3.6 Other Issues

3.6.1 Similarity and Distance

3.6.2 Parameter Choice in Sequence Comparison

3.6.3 String Matching and Exact Sequence Comparison

Summary

Exercises

Bibliographic Notes

Fragment Assembly of DNA

4.1 Biological Background

4.1.1 The Ideal Case

4.t.2 Complicati***

4.1.3 Alternative Methods for DNA Sequencing

4.2 Models

4.2.1 Shortest Common Superstring

4.2.2 Rec***truction

4.2.3 Multicontig

4.3 Algorithms

4.3.1 Representing Overlaps

4.3.2 Paths Originating Superstrings

4.3.3 Shortest Superstrings as Paths

4.3.4 The Greedy Algorithm

4.3.5 Acyclic Subgraphs

4.4 Heuristics

4.4.1 Finding Overlaps

……

5 Physical Mapping of DNA

6 Phylogenetic Trees

7 Genome Rearrangements

8 Molecular Structure Prediction

9 Epilogue:Computing with DNA

Answers to Selected

References

Index

暂无相关内容，正在全力查找中

暂无出版社相关信息，正在全力查找中！

暂无相关书籍摘录，正在全力查找中！

在线阅读地址：计算分子生物学导论(英文版)在线阅读

在线听书地址：计算分子生物学导论(英文版)在线收听

在线购买地址：计算分子生物学导论(英文版)在线购买

暂无原文赏析，正在全力查找中！

书籍介绍